Upstream USA
Upstream USA reported $142.1 million in revenue and $47.7 million in expenses for calendar year 2025. Of every $100 it spent, $77.95 went to program services, $13.14 to management and general costs and $8.91 to fundraising. Its largest source of revenue was contributions and grants: 94.0% of the total. The highest compensation it reported for one person was $563,142 (Co-Founder and CEO). 144 people received more than $100,000 in reportable compensation. Revenue rose 150% between 2019 and 2025. Source: Form 990, 2025.
Where $100 of spending went
Calendar year 2025 · Form 990, Part IX, line 25 · total expenses $48MFor context, the median across 5,634 covered health care charities: $86.19 programs, $13.81 management, $0.00 fundraising (medians computed separately, so they may not sum to $100).
Where $100 of revenue came from
Calendar year 2025 · Form 990, Part VIII · total revenue $142MOther revenue was negative: −$9,777. The bar shows the positive sources only.
The 990 scorecard · same measures for every charity, no grades
| Measure | 2025 | Median |
|---|---|---|
| Program services Part IX 25(B) ÷ 25(A) | 77.9% | 85.6% |
| Management & general Part IX 25(C) ÷ 25(A) | 13.1% | 13.7% |
| Fundraising Part IX 25(D) ÷ 25(A) | 8.9% | 0.0% |
| Fundraising cost per $1 of contributions Part IX 25(D) ÷ Part VIII 1h | $0.03 | $0.00 |
| Contributions & grants share of revenue Part VIII 1h ÷ 12 | 94.0% | 1.3% |
| Government grants share of revenue Part VIII 1e ÷ 12 | 0.0% | 0.1% |
| Program service revenue share Part VIII 2g ÷ 12 | 0.0% | 93.7% |
| Highest reported compensation Part VII-A, columns D–F | $563,142 | $975,831 |
| Highest compensation as share of expenses Part VII-A ÷ Part IX 25(A) | 1.18% | 1.34% |
| People paid over $100,000 Part VII, line 2 | 144 | 27 |
| Net assets, in months of expenses Part X 33(B) ÷ monthly expenses | 84.2 | 6.6 |
| Independent voting board members Part VI 1a–1b | 12 of 13 | 88.9% |
A median is context, not a target: hospitals, universities, food banks and grantmakers spend in very different ways. What these measures can and can't tell you.
What the money paid for, in its own words
2025 · Form 990, Part III · the three largest programs by expenseUpstream is working to achieve impact at scale across the United States. In 2025 Upstream continued to expand nationally toward our goal to reach 5 million patients with the addition of new partnerships serving 445,000 patients of reproductive age. As of the end of 2025 Upstream has established partnerships with healthcare organizations in 36 states including DC: Alabama Arkansas Arizona California Colorado Connecticut District of Columbia Delaware Florida Georgia Iowa Idaho Illinois Indiana Kansas Louisiana Massachusetts Maryland Michigan Missouri Mississippi North Carolina New Jersey Nevada…
Highest reported compensation
2025 · Form 990, Part VII, Section A · roles as filed; names are in the filing, not here| Role | From this org | From related orgs | Other | Total |
|---|---|---|---|---|
| Co-Founder and CEO Director/trustee, officer, 40.00 hrs/week | $517,721 | $0 | $45,421 | $563,142 |
| President and COO Officer, 40.00 hrs/week | $363,669 | $0 | $51,114 | $414,783 |
| Treasurer and CFO Officer, 40.00 hrs/week | $341,516 | $0 | $41,345 | $382,861 |
| Lead Clinical Advisor Highest compensated employee, 24.00 hrs/week | $339,327 | $0 | $17,477 | $356,804 |
| Clinical Advisor Highest compensated employee, 32.00 hrs/week | $295,967 | $0 | $40,082 | $336,049 |
| Lead Clinical Trainer Highest compensated employee, 32.00 hrs/week | $304,726 | $0 | $17,656 | $322,382 |
| Chief Dev Ext Aff Off Key employee, 40.00 hrs/week | $277,957 | $0 | $39,061 | $317,018 |
| Senior Research Advisor Highest compensated employee, 40.00 hrs/week | $246,942 | $0 | $44,866 | $291,808 |
144 people received more than $100,000 in reportable compensation from Upstream USA (Part VII, line 2). Compensation of current officers, directors and key employees totaled $1.9M (Part IX, line 5).
7 years of filings
Form 990, Parts I, VII, IX and X · each row is that year's own filing, linkedGovernance answers, as filed
2025 · the organization's own yes/no answers; explanations, if any, are in Schedule O of the filing · what each means- Voting board members, and how many are independent Part VI, lines 1a–1b13 · 12 independent
- Audited financial statements Part XII 2bYes
- Conflict-of-interest policy Part VI 12aYes
- Whistleblower policy Part VI 13Yes
- Document retention policy Part VI 14Yes
- Independent process for top executive pay Part VI 15aYes
- Board given the 990 before filing Part VI 11aYes
- Family or business ties among insiders Part VI 2No
- Aware of a significant diversion of assets Part VI 5No
- Excess benefit transaction with an insider Part IV 25aNo
- Loans to or from insiders outstanding Part IV 26No
- Lobbying, or a 501(h) election in effect Part IV 4Yes
- Over $15,000 of professional fundraising services Part IV 18Yes
- Over $10,000 of activity outside the U.S. Part IV 14bNo
- Employees Part I, line 5202
- Volunteers Part I, line 613
Largest outside contractors
2025 · Form 990, Part VII, Section B · businesses only| Azara Healthcare LLC Data Extraction/Analysis | $2,090,179 |
| LinkedIn Corporation Marketing/Paid Media | $346,068 |
| The Holding Co Lab LLC Digital Product Design Work | $250,000 |
| Ropes & Gray LLP Legal Consulting | $180,299 |
Individuals listed as contractors are left out. 18 contractors were paid more than $100,000 in all.
Private foundation grants it received
21 private foundations reported grants to Upstream USA totaling $9.4M on their tax year 2023 Form 990-PF returns. See which foundations, on WHOFUNDS.
Source: WHOFUNDS open grant graph, matched from Form 990-PF Part XV.
Correct a figure or respond
Every number above is copied from Upstream USA's own Form 990. If one doesn't match the filing, that's our error and we'll fix it. If you work for Upstream USA, you can publish a response that is linked from this page.
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Of every $100 Upstream USA spent in 2025, $77.95 went to programs. The full breakdown, from its IRS Form 990:
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All health care charities · Largest charities in Massachusetts
Questions people ask
How much of Upstream USA's spending goes to programs?
In calendar year 2025, Upstream USA reported that 77.9% of its $47.7 million in expenses went to program services, 13.1% to management and general and 8.9% to fundraising (Form 990, Part IX).
How much does Upstream USA pay its top executive?
The largest total compensation Upstream USA reported for one person in calendar year 2025 was $563,142, for the role of Co-Founder and CEO (Form 990, Part VII, including compensation from related organizations and other compensation).
Where does Upstream USA get its money?
Of $142.1 million in revenue in calendar year 2025, 94.0% came from contributions and grants and 0.0% from program service revenue (Form 990, Part VIII).
Is Upstream USA a registered charity?
The IRS lists EIN 35-2581424 as a 501(c)(3) organization (publicly supported organization (170(b)(1)(a)(vi))), and its records show contributions as tax-deductible. Form 990 filings on record here cover tax years 2019, 2020, 2021, 2022, 2023, 2024, 2025. A filing shows what the organization reported; it doesn't by itself show whether a program works.
Sources
- 2025: Form 990 for calendar year 2025, object 202641839349300404 · read the filing · XML
- 2024: Form 990 for calendar year 2024, object 202531749349300003 · read the filing
- 2023: Form 990 for calendar year 2023, object 202441729349301314 · read the filing
- 2022: Form 990 for calendar year 2022, object 202341459349301324 · read the filing
- 2021: Form 990 for calendar year 2021, object 202212039349300746 · read the filing
- 2020: Form 990 for calendar year 2020, object 202121839349300512 · read the filing
- 2019: Form 990 for calendar year 2019, object 202022049349300822 · read the filing
All filings for EIN 35-2581424: ProPublica Nonprofit Explorer · IRS Tax Exempt Organization Search. Figures are as the organization reported them; we have not audited them.