| 1 | Entera Bio Ltd. | Intl | $275M | $275M | Aug 12 |
| 2 | Precision Neuroscience Corp | NY | $250M | indefinite | Sep 28 |
| 3 | AdvanCell, Inc. rookie | MA | $218M | $315M | Jul 16 |
| 4 | Immunic, Inc. | Intl | $200M | $200M | Mar 4 |
| 5 | Ollin Biosciences, Inc. rookie | TX | $156M | $330M | Jun 24 |
| 6 | Rightway Healthcare, Inc. | NY | $155M | $155M | Sep 8 |
| 7 | Jasper Therapeutics, Inc. rookie | CA | $132M | $132M | Aug 5 |
| 8 | SonoThera, Inc. | CA | $125M | $125M | Jun 30 |
| 9 | Solstice Oncology, Inc. rookie | MA | $121M | $298M | Mar 9 |
| 10 | Iliad Biotechnologies, Inc. rookie | FL | $116M | $116M | Feb 20 |
| 11 | Quince Therapeutics, Inc. | CA | $115M | $186M | Jun 11 |
| 12 | Rakuten Medical, Inc. | CA | $112M | $117M | Apr 13 |
| 13 | Climb Bio, Inc. | MA | $110M | $110M | May 4 |
| 14 | Strand Therapeutics Inc. | MA | $108M | $120M | Mar 17 |
| 15 | Candid Group, Inc. rookie | CA | $105M | indefinite | Jul 22 |
| 16 | Imperative Care, Inc. | CA | $100M | $100M | Mar 20 |
| 17 | American Republic Insurance Co rookie | IA | $95M | $95M | Oct 22 |
| 18 | Georgiamune, Inc. rookie | MD | $92.7M | $132M | Aug 17 |
| 19 | VantAI Holdings, Inc. rookie | NY | $86.3M | $88.5M | Jan 21 |
| 20 | Bridge To Life Ltd | GA | $82.5M | $82.5M | Oct 21 |
| 21 | Alpfa Medical, Inc. rookie | CA | $80.3M | $100M | Sep 28 |
| 22 | Alzheon, Inc. | MA | $78.8M | $500M | Sep 10 |
| 23 | Cellanome, Inc. | CA | $75.9M | $75.9M | Jun 22 |
| 24 | Lycia Therapeutics, Inc. | CA | $75M | $75M | Jun 25 |
| 25 | Altesa BioSciences, Inc. | GA | $75M | $75M | Feb 23 |
| 26 | EXUMA Biotech Corp. | FL | $70M | $70M | Aug 20 |
| 27 | Ratio Therapeutics, Inc. | MA | $70M | $70M | Jul 31 |
| 28 | Mirum Pharmaceuticals, Inc. | CA | $68.5M | $68.5M | Jan 29 |
| 29 | Integrated Biosciences, Inc. rookie | CA | $68.4M | $100M | Aug 5 |
| 30 | Iambic Therapeutics, Inc. | CA | $66M | $66.5M | Sep 9 |
| 31 | Superluminal Medicines, Inc. | MA | $65.5M | $65.5M | Sep 3 |
| 32 | Stipple Bio, Inc. | MA | $65.1M | $100M | Apr 6 |
| 33 | AirNexis Therapeutics, Inc. rookie | CA | $62M | $200M | Mar 9 |
| 34 | Gilgamesh Pharma Inc. | NY | $60M | $60M | Mar 24 |
| 35 | Moonwalk Biosciences, Inc. | CA | $60M | $70.2M | Sep 14 |
| 36 | BAMF Health Parent, Inc. rookie | MI | $59.7M | $130M | May 19 |
| 37 | Terrestrial Bio, Inc. | MA | $57.3M | $83.5M | Mar 19 |
| 38 | Alveus Therapeutics, Inc. rookie | PA | $56.9M | $111M | Jan 14 |
| 39 | Women's and Children's Health Technology EU Fund II SCSp rookie | Intl | $56.4M | $200M | Aug 11 |
| 40 | Typewriter Therapeutics, Inc. rookie | MA | $56.3M | $56.3M | Sep 21 |
| 41 | Contraline, Inc. | VA | $55.8M | $116M | Jun 10 |
| 42 | Claris Biotherapeutics, Inc. | CA | $55.7M | $121M | Aug 7 |
| 43 | Lexicon Pharmaceuticals, Inc. | TX | $55.7M | $59.1M | Feb 17 |
| 44 | Kaigene, Inc. | MD | $55M | $73.3M | Oct 14 |
| 45 | Gt Medical Technologies, Inc. | AZ | $50.1M | $100M | Jul 22 |
| 46 | Quoin Pharmaceuticals Ltd. | VA | $50M | $50M | Sep 10 |
| 47 | Route 92 Medical, Inc. | UT | $50M | $50M | Apr 20 |
| 48 | Caspian Therapeutics, Inc. rookie | CA | $50M | $50M | Sep 23 |
| 49 | Click Therapeutics, Inc. | NY | $50M | $50M | Oct 1 |
| 50 | Gravie, Inc. | MN | $50M | $93.8M | Jun 22 |